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Many patients ask, “Amlodipine vs Telmisartan: which is better for high BP?”   What Is Amlodipine? Amlodipine is a Calcium Channel Blocker (CCB) . Amlodipine vs Telmisartan: Major Differences Feature Amlodipine Telmisartan Drug Class Calcium Channel Amlodipine works faster.  BP reduction may begin within 2–4 hours. Amlodipine commonly causes leg swelling, while Telmisartan is usually well tolerated.